SHOX2 and obesity due to melanocortin 4 receptor deficiency: In particular, there is clear evidence for depot specific expression of developmental genes like Short Stature Homeobox 2 (Shox2), T-Box 15 (Tbx15), Engrailed 1 (En1), and Homeobox-genes (e.g., Hoxa5, Hoxc8, and Hoxc9) which have been suggested to play a role in the origin of obesity and body FD (9).