JAK2 is a well-known upstream regulator of STAT3 activation in cancer cells (Bowman et al., 2000), and the JAK2/STAT3 pathway has been shown to alter the expression of key oncogenes and tumor suppressor genes to enhance the growth, survival, and metastasis of CRC cells (Xiong et al., 2008). The gene discussed is STAT3; the disease is cancer.