LRRK2 and late-onset Parkinson disease: The clinical presentation of LRRK-G2019S carriers, including both motor and non-motor symptoms, is similar to idiopathic PD, and the majority of less common pathological LRRK2 mutations appear to act through mechanisms similar to G2019S (Greggio et al., 2006; Smith et al., 2006; Paisan-Ruiz et al., 2013; Mir et al., 2018).