LRRK2 and late-onset Parkinson disease: That trafficking pathways are relevant gains support from data showing that Rab7L1/Rab29, a PD risk factor gene, activates LRRK2, promotes its location to Golgi, and potentiates its kinase activity (Kuwahara et al., 2016; Liu et al., 2018; Purlyte et al., 2018).