SOCS3 and Sepsis: Among these functions, induction of miR-146a expression in splenic macrophages prevents excessive inflammation and sepsis-induced multiple organ injury [36]; miR-151-3p inhibits LPS-induced IL-6 production by targeting STAT3 [37], miR-142-3p, and miR-let-7g increase IL-6 production in neonatal polymorphonuclear leukocytes induced via posttranscriptional inhibition of LPS [38], and miR-19a enhances JAK-STAT signaling by regulating SOCS3 expression [39].