These data are consistent with a study conducted in T1D individuals with poor glycemic control that showed increased production of LTB4 by polymorphonuclear leukocytes [25] and, together with the finding of higher LTB4R expression in T1D individuals in comparison to nondiabetic controls, reinforce the role of hyperglycemia in triggering sterile inflammation [12]. This evidence concerns the gene LTB4R and Hyperglycemia.