We also investigated whether the mRNA expressions of LTB4R, ALOX5, and MYD88 and the plasma concentrations of LTB4 would be modulated by ACEI, ARB, and statin; the mRNA expression of LTB4R was significantly lower in T1D individuals using ACEI after adjustment for sex, age, HbA1C, diabetes duration, and use of ARB and statin (P = 0.015; Figure 5(a)). This evidence concerns the gene ALOX5 and type 1 diabetes mellitus.