DDOST and Hyperglycemia: The higher expressions of DDOST and SIRT1 in the group presenting the worst metabolic control probably reflect a compensatory defense mechanism against the oxidative stress triggered by hyperglycemia, since DDOST encodes AGE-R1, a receptor involved in AGE clearance and in the activation of sirtuin-1, among other effects which ultimately restrict prooxidative and proinflammatory pathways [6].