In other words, proteins with high net-influence that localize at the triple-overlapped part of the AD, psychosis and Vitamin D network, like CACNA1C, COMT, NOTCH4 and DRD3, possess the ability to play an important role in the crosstalk among AD and psychosis by delivering Vitamin D’s effect to the transiting hub connecting the AD network and psychosis network. This evidence concerns the gene COMT and Alzheimer disease.