In ALK5ΔCD8 mice there was a decrease in tumor infiltrating naïve CD8+ T cells (CD44LO/CD62L+), and an increase in effector CD8+ T cells (CD44INTCD62L−) (Fig. 3c), also defined by Ly6C+CD62L−(Fig. 3d)34,35. The gene discussed is CD8A; the disease is neoplasm.