Of note, the frequency of tumor-infiltrating CXCR3+CD8+ T cells steadily decreases over time, with complete loss of CXCR3+ cells 21 days post implantation in MC38 (Supplementary Fig. 5h), which may reflect the development of an exhausted phenotype where CXCR3 is known to be downregulated40. The gene discussed is CXCR3; the disease is neoplasm.