While this can function in suppressing T cell activation in an autologous manner, a study using imiquimod-induced murine psoriasis demonstrated that VISTA inhibits the activation of DCs and the production of IL-23 following TLR 7 activation.110 The same study also demonstrated that VISTA negatively regulates the activation of IL-17-producting γδ T cells and Th17 cells.110 Therefore, it is conceivable that at least some aspects of VISTA blockade in boosting antitumor immunity involve releasing the brakes on innate immunity. The gene discussed is VSIR; the disease is psoriasis.