Plasma membrane proteases such as ADAM17/TACE are involved not only in the proteolytic cleavage and generation of oncogenic ligands such as EGFR ligand TGFα, but also in shedding of cell surface molecules including MICA/B and FcγRIIA that can help cancer cells evade NK cells.99 100 Proteases such as ADAM17/TACE have complex effect on inflammation as their substrate-derived products can boost inflammation such as through CD154, soluble TNFα and IL-6R, as well as dampen T cell activation such as by cleaving cell adhesion molecules as L-selectin (CD62L). This evidence concerns the gene ADAM17 and cancer.