Mertk−/− mice have been shown to be more resistant to tumor growth in various murine tumor models.114 115 Whether this is a result of disabling MERTK function specifically in DCs resulting in their enhanced activation or if the loss of MERTK-dependent phagocytic function of macrophages (please see below) also contribute to anti-immunity remains unknown. The gene discussed is MERTK; the disease is neoplasm.