NPTX2 and early-onset autosomal dominant Alzheimer disease: Cerebrospinal fluid (CSF) neuronal pentraxin (NPTX)2 levels are reduced in patients with Alzheimer’s disease (AD) compared with controls.12 14 17 In AD, low CSF NPTX2 levels are associated with cognitive impairment and subsequent memory decline, as well as hippocampal atrophy and subsequent medial temporal lobe atrophy.12 17