The contribution of REDD1 to human cancer has remained uncertain, as Redd1-null mice do not die prematurely or exhibit tumor predisposition, and studies have reported mixed results regarding the contribution of REDD1 to cell proliferation and survival relevant to tumorigenesis (DeYoung et al. 2008; Reuschel et al. 2015; Lipina and Hundal 2016). Here, DDIT4 is linked to neoplasm.