Previous studies identified high levels of phosphorylated collapsin response mediator protein 2 (CRMP2) [23], an axonal specification protein that also regulates microtubule assembly, in neurofibrillary tangles and abnormal neurites from human AD brains, suggesting that accumulation of CRMP2 may be an early event in AD [20]. Here, DPYSL2 is linked to Alzheimer disease.