It is noteworthy that despite the presence of trehalase in the gut, orally administered trehalose has been proven to exert significant biological effects in mouse models of many different diseases, such as Parkinson’s, Alzheimer’s, muscular dystrophy, Huntington’s disease, ALS, prion’s disease, OPMD, obesity, hepatic steatosis, diabetes, or chronic ischemia [35, 53, 54]. This evidence concerns the gene TREH and prion disease.