In addition, vitamin D3-induced transcription factors (GO Cellular Component (GO-CC) “nuclear transcription factor complex”, Additional File 3: Supplementary Fig. S2, Additional File 4) included Sox2, whose role in OL differentiation was recently reported (Kuhbandner, 2018; Zhang et al., 2018) and CCAAT/enhancer binding protein beta (Cebpb), a VDR-responsive gene that controls the differentiation of myeloid leukaemia cells (Marchwicka & Marcinkowska, 2018). The gene discussed is SOX2; the disease is myeloid leukemia.