Moreover, H19 is a biomarker for diagnosis of cholangiocarcinoma with high sensitivity and specificity (Han et al. 2018) and H19 can sponge Let-a/b, miR-372 and miR-373 to enhance IL-6 production, CXCR expression and tumor-related inflammation, and malignant behaviors of cholangiocarcinoma (Wang et al. 2016). Here, IL6 is linked to cholangiocarcinoma.