APP and brain cancer: The upregulation of miR-195 may avoid dendritic degeneration and neuronal death induced by chronic brain hypoperfusion via involvement of the N-APP/DR6/caspase pathway (Chen et al. 2017), and miR-195 was strongly correlated with glioblastoma multiforme, which was known as a very common malignant brain tumor (Lakomy et al. 2011).