Having observed radiation-mediated enhancement of NY-ESO-1 cancer cell antigen presentation to CD8+ T cells with cell lines of three different cancers—esophagus, lung (Figure 1), and kidney (A498 cell line) [17]—we sought to understand the molecular basis of this phenomenon using a panel of three HNSCC and five NSCLC human cell lines (Table 1). The gene discussed is CD8A; the disease is cancer.