As for the PPARγ related substances, apigenin, a food-derived compound, were reported significantly ameliorated NAFLD and obesity-induced metabolic syndrome by acting as a PPARγ modulator through Nrf2 (nuclear factor E2-related factor 2), inhibiting the lipid metabolism and oxidative stress abnormity [45,46]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.