Indeed, multiple studies have provided evidence on progression of CML and MPN to fully transformed leukemias by selection for mutations in TP53 or other major DDR components [20,21,22], but the detailed hierarchical nature of cooperation between the DDR and inflammatory cytokine network in leukemogenesis has remained poorly understood. Here, TP53 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.