In our recent publication, we further elaborated on the concept of protection mechanisms that guard myeloproliferative progenitors from cell-intrinsic and cell-extrinsic DNA damage and thus DDR, facilitating creation of a barrier preventing cell cycle arrest, myelofibrosis, and rapid malignant transformation in JAK2 V617F-positive PV. The gene discussed is JAK2; the disease is acquired polycythemia vera.