Detection of T-cells with a distinct immunophenotype of low light scatter and a CD3-positive, CD7-negative/low and/or CD8-positive/low marker expression profile in patients with lymphadenopathy, night sweats and/or fever reflects a reactive self-limited T-cell expansion and should therefore be reported by diagnostic flow cytometry laboratories in order to provide supportive diagnostic information to physicians. Here, CD7 is linked to Lymphadenopathy.