Still, taken together, the data demonstrate that the junctional localization of RNAi components is lost in poorly differentiated colon cancer cells in association with the disruption of junctional localization or loss of expression of PLEKHA7, independently of their overall expression levels or the overall presence of Ecad-p120-mediated cell-cell adhesion. The gene discussed is PLEKHA7; the disease is malignant colon neoplasm.