PLEKHA7 and colonic neoplasm: The broad dysregulation of the junctional PLEKHA7-RNAi machinery that we have observed, together with the possible existence of multiple modes of regulation and the fact that colon cancer is a multifactorial disease, raise the possibility that the junctional RNAi complex is a focal point at which several pathways converge to sustain colon cell homeostasis and that the dysregulation of either one of them could promote disease progression, through RNAi-miRNA dysregulation.