In this light, altered signaling between gut bacteria and their host has recently been implicated in the pathophysiology of EDs, whereas the enterobacterial caseinolytic protease B (ClpB) protein may play a key role as an antigen mimetic of α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide [5,6]. Here, CLPB is linked to Ehlers-Danlos syndrome.