Taken together, it can be concluded that the transport metabolons, formed between CAIX and the membrane transporters NHE1, NBCe1, AE2, MCT4, and NCX1, play a crucial role in shaping intracellular and extracellular pH gradients at the protruding front of migrating tumor cells, thereby promoting tumor cell migration, invasion, and ultimately metastasis. This evidence concerns the gene SLC8A1 and neoplasm.