Based on the obtained regression models it was shown that allele G in rs806381 gene CNR1, allele G in rs7799039 gene LEP, higher BMI, older age and diabetes were independently associated with higher As-U concentration; while allele A in rs1049353 gene CNR1 and allele A in rs12720071 gene CNR1 were independently associated with lower As-U concentration. Here, LEP is linked to diabetes mellitus.