PHAX and renal cell adenocarcinoma: Here, we have made use of a differential network algorithm called regulatory impact factor (RIF) analysis, which asks the following question of the transcriptome data: “Following sunitinib treatment, which molecule changes its position in the RCC regulatory network the most, irrespective of its own mRNA expression level?” In this context, we find the answer to this question to be the mRNA encoding the protein PHAX.