PHAX and neoplasm: In contrast to UT and PHAX siRNA-treated ccRCC organ cultures, which showed only a few TUNELpositive tumour cells and vascular ECs (5.0% ± 0.1% and 5.2% ± 0.9%), cultures treated with high dose sunitinib (200 μM) demonstrated a statistically significant increase in TUNELpositive cells (84.7% ± 1.2%) (mainly consisting of tumour cells and vascular ECs).