Additionally, Calin et al. documented that a combination of Uc160 expression with the expression of four other UCRs (Uc269, Uc215, Uc346, and Uc348) was able to differentiate between two main chronic lymphocytic leukemia (CLL) prognosis groups [20]. Here, RFX4-AS1 is linked to B-cell chronic lymphocytic leukemia.