Pathway inhibitors such as ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, idelalisib, a phosphoinositide 3-kinase inhibitor (PI3K), and venetoclax, a B-cell lymphoma-2 (BCL2) inhibitor, vastly outperform CIT in both response rates and PFS in cases of TP53 disrupted CLL including those with r/r disease [47,48]. Here, BTK is linked to B-cell chronic lymphocytic leukemia.