Activating receptors, including Natural killer group 2D (NKG2D), DNAX accessory molecule-1 (DNAM-1) and the natural cytotoxicity receptors NKp46, NKp44 and NKp30, recognize inducible ligands that are specifically upregulated on infected, cancer and stressed cells [4,5,10,11,12]. The gene discussed is CD226; the disease is cancer.