CD4 and colorectal carcinoma: Although previous studies based on bulk RNA detection inferred the association between increased Th1 signature and the MSI status in CRC patients,152 scRNA‐seq analysis further illustrated that only CXCL13+BHLHE40+ Th1‐like cluster but not the classical CD4+ Tem cluster in CRC was preferentially enriched in MSI patients and could be accountable for the favorable response of these patients to CPIs.