In remyelinating multiple sclerosis lesions, the gene expression pattern of the identified experimental remyelination network orthologues was more consistent with early remyelination in the CPZ model, i.e. upregulation of HSPG2 and downregulation of signal transducer and activator of transcription 1 (STAT1) and Thrombospondin-4 (THBS4) (Fig 5B). Here, THBS4 is linked to multiple sclerosis.