Our results of elevated endocannabinoid levels do not contradict with this hypothesis, since it can be speculated that the overall endocannabinoid tone is still reduced in TS, for example due to a reduced number or reduced sensitivity of cannabinoid CB1/CB2 receptors or an overactivity of the degradation enzymes MAGL (for 2-AG) and fatty acid amide hydrolysis (FAAH, for AEA). Here, CNR1 is linked to Timothy syndrome.