Besides the type of fat, also the characteristics of the lipid droplet itself have been implicated in the etiology of type 2 diabetes, with cells of patients with type 2 diabetes mellitus (T2DM) being characterized by larger lipid droplets—mainly in type 2 muscle fibers—when compared to insulin-sensitive endurance-trained athletes who are characterized by more but smaller lipid droplet [3]. Here, INS is linked to type 2 diabetes mellitus.