The genomic landscape of MM shows frequent inactivation of the CDKN2AB locus that encodes for the p16INK4A, p15INK4B, and p14ARF cell cycle inhibitor proteins and the Neurofibromatosis Type 2 (NF2) tumor suppressor gene (Cheng et al., 1994; Sekido et al., 1995). Here, CDKN2A is linked to Miyoshi myopathy.