In our previous study, we found that small G protein signaling modulator 3 (SGSM3), a partner of Cx43, contributes to MI in rat hearts [29], and inhibiting the protective effects against oxidative stress with kenpaullone was shown to involve Cx43 and SGSM3 interactions in cardiomyocytes [30]. Here, SGSM3 is linked to myocardial infarction.