IFIH1 and viral infectious disease: IFIH1 involved in the antiviral cascades’ activation in response to viral infection (including encephalomyocarditis virus (EMCV) and Mengo encephalomyocarditis virus (ENMG), dengue virus (DENV), west Nile virus (WNV), and reovirus), via induction of Type-1 INF and proinflammatory cytokines.