For instance, GRHL2 (OMIM: 608576) known to cause recessive ectodermal dysplasia/short stature syndrome, which involves nail dystrophy [19], was correctly linked to Nail dystrophy with recessive MOI by Phenogenon (HGF score: 10.54). The gene discussed is GRHL2; the disease is nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome.