For example, considering patients affected by both ‘Rod-cone dystrophy’ (HP:0000510) and ‘Hearing impairment’ (HP:0000365), the top two genes predicted are USH2A (HGF: 9.53) and ADGRV1 (HGF: 8.31), both known to cause Usher syndrome that affects both visual and hearing systems. The gene discussed is USH2A; the disease is Hearing impairment.