S100A8 and inflammatory response: East Asian-type CagA has been reported to be more virulent than Western-type CagA due to greater binding to the Src homology 2 domain-containing protein tyrosine phosphatase 2 [44]; thus, it has ability to generate more severe gastric mucosal inflammation and is also associated with the development of atrophic gastritis and gastric cancer and it is described as lower PGI/II ratio value.