Moreover, expression of Cx3cr1 and Ccr2 in macrophages were not changed after deletion of Foxm1. Thus, FOXM1 activates Cx3cr1 and Ccr2 in macrophages during lung cancer and acute liver injury/repair [24, 25], but is not doing so during lung fibrosis. The gene discussed is CX3CR1; the disease is pulmonary fibrosis.