Moreover, our findings are consistent with data from a large population-based study of subjects with preserved renal function without CKD, which showed that PTH levels increase earlier than FGF23 levels as kidney function decreases and that high FGF23 levels are more closely associated with low levels of 1,25(OH)2D than with excessive renal phosphate wasting (Dhayat et al., 2016). Here, FGF23 is linked to chronic kidney disease.