In the present study, we report for the first time that micromolar GGA causes inflammatory cell death, pyroptosis, in human hepatoma HuH-7 cells via TLR4 signalling, where both mitochondrial hyperproduction of superoxides and nuclear translocation of NF-κB play essential roles to prime the NLRP3 inflammasome. The gene discussed is TLR4; the disease is hepatocellular carcinoma.