In support of this contention, knockdown of ATG7 and VPS34, key players for autophagy activation, suppressed tumor growth induced by MAGEA6 downregulation, consistent with autophagy activity playing a key role in promoting tumor growth in response to MAGEA6 depletion in BxPC-3 (Figure 6D and Figure 6—figure supplement 2). Here, PIK3C3 is linked to neoplasm.