The fact that MAGEA6 functions as a bona fide oncogene in PDAC but is subjected to degradation-prone mutation leads us to hypothesize that (1) MAGEA6 is an autophagy coordinator manipulating autophagy activity at different disease stages to promote tumor initiation and further development and (2) the nutrient-sensing stability of MAGEA6 provides autophagy regulation for better tumor survival under metabolically stressed conditions. Here, MAGEA6 is linked to neoplasm.