MAGEA1 and cancer: Most of these gene aberrations are missense mutations, and they are clustered on MAGEA1, A3, A4, A6, A8, A10, A11, and A12. As a group, MAGEA gene family members, are more frequently mutated in TCGA lung cancer patients and pancreatic cancer patients when compared to a randomized gene set of 1000 genes with similar size to MAGEAs (Figure 1B), suggesting that mutation of MAGEA genes is functionally important in cancer.