In agreement with the anti-tumorigenic role of MAGEA6 at a late disease stage, knockdown of MAGEA6 in the transformed PDAC cell line BxPC-3, which has high endogenous wild-type MAGEA6 expression, dramatically increased tumor volume compared with xenografts without MAGEA6 knockdown (Figure 6C top and Figure 6—figure supplement 2). This evidence concerns the gene MAGEA6 and neoplasm.