REN and hypertensive disorder: Another study18 reported that the activation of the endothelin‐1 and the renin suppression are involved in sunitinib‐induced hypertension, proteinuria, and renal damage, determining lower activity of the NO system; this effect, as reflected by the decrease in urinary nitric oxide (NO) metabolites and cyclic guanosine 3′,5′‐monophosphate, has been also described by Henri et al.16