Another study18 reported that the activation of the endothelin‐1 and the renin suppression are involved in sunitinib‐induced hypertension, proteinuria, and renal damage, determining lower activity of the NO system; this effect, as reflected by the decrease in urinary nitric oxide (NO) metabolites and cyclic guanosine 3′,5′‐monophosphate, has been also described by Henri et al.16 Here, REN is linked to Hypertension.