CDK6 and myelodysplastic syndrome: In addition to telomer abnormalities, when compared to healthy volunteers, CD34+ HSPCs from patients with AA showed down-regulation of several cell cycle “checkpoint” genes, such as Fanconi anemia complementation group (FANCG), c-myb, c-myc, cyclin-dependent kinase 6 (CDK6), CDK2 and cyclins E and A which would also be consistent with the ultimate development of premalignant or aneuploid cells and conversion to MDS/AML [68].