While alpha and beta endocrine cells are stimulated to release glucagon and insulin, respectively (Da Silva Xavier 2018; Theis and Lickert 2019), discordance in both cell types has been shown to increase disease pathogenesis in type 1 and type 2 diabetes (Ackermann et al. 2016; Brissova et al. 2018; Tritschler et al. 2017). The gene discussed is INS; the disease is type 2 diabetes mellitus.