Altogether, three SNPs (KNG1 rs5030062, rs710446 and F12 rs1801020) were associated with plasma kallikrein activity (Table 1, ESM Results and ESM Fig. 2a, b) and selected for further analyses in the larger cohort of 4400 individuals (adjusted for age, sex, diabetes duration, RAAS-blocker therapy and the two first principal components). The gene discussed is KLK4; the disease is diabetes mellitus.