Among the 15 target genes of BMD and osteoporosis susceptibility loci, SPTBN1 is a molecular scaffolding protein which has been recognized as an osteoporosis susceptibility gene (Estrada et al., 2012; Chen et al., 2016), and it shows co-expression with alpha-actinin binding and cell adhesion gene in the bone (Calabrese et al., 2017). Here, SPTBN1 is linked to osteoporosis.