In aging-prevalent diseases, such as AD, tauopathies, Lewy body diseases, Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and Creutzfeldt-Jakob disease, astrogliopathy is often characterized by increased GFAP and abnormal protein aggregates (Ferrer, 2017). This evidence concerns the gene GFAP and amyotrophic lateral sclerosis.