In agreement with this result, a previous study showed that K4DT cells derived from the human skeletal muscle cells of patients with myotonic dystrophy type 1 (DM1) retained the original pathogenic condition, such as the abnormal splicing of exon 11 of BIN1 (bridging integrator-1) and exon 5 of MBNL1 (muscle-specific splicing factors muscle blind-like protein 1) (Pantic et al., 2016). This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.