Notably, HGSC with BRCA dysregulations, including BRCA1/BRCA2 mutations and BRCA1 promoter hypermethylation, are associated with specific morphological “SET” patterns: Solid, pseudoEndometrioid, and Transitional cell carcinoma-like histology (80, 81). The gene discussed is BRCA1; the disease is transitional cell carcinoma.