CLU and Alzheimer disease: Other risk genes for AD are also associated with cholesterol, including ApoJ/CLU (which interacts with ApoE to form cholesterol-carrying lipoproteins) [17–19], ABCA7 (a membrane cholesterol transporter) [17,20], and SORL1 (an ApoE receptor involved in internalizing cholesterol-carrying lipoproteins) [17,18].