Although not associated with any specific brain region, PRKCI immunostaining was observed not only in AD, but also in Pick bodies of hippocampal dentate gyrus neurons and neocortical neurons in Pick Disease patients, globose triangles and tufted astrocytes in subthalamic, mesencephalic and cerebellar dendate nuclei, as well as in the inferior olive in Progressive Supranuclear Palsy patients, and tau-positive astrocytic inclusions in the cerebral cortex, and neuronal and glial inclusions in the basal ganglia in patients with Corticobasal degeneration [159]. This evidence concerns the gene PRKCI and Alzheimer disease.