In a superoxide dismutase 1 (SOD1) (G93A) mouse model of amyotrophic lateral sclerosis (ALS), Tury et al. [160] observed that aPKC expression was increased in motor neurons of the lumbar spinal cord and accumulated in extracellular aggregates in increasing amounts with disease progression. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.